What SBIR grants fund
SBIR grants fund research and development by small businesses. Awards often support feasibility studies, prototypes, technical validation, and commercialization steps before venture capital or procurement revenue is available.
Federal R&D grants
SBIR Grants for Startups & Small Businesses
Find SBIR grants and federal R&D funding for startups and small businesses developing technology, science, defense, health, energy, or commercialization projects.
Last updated
Hub content and matching listings are refreshed from the live Bootstrap Directory database.
Data sources
Sources include Grants.gov, SAM.gov, SBIR.gov, CareerOneStop, state agencies, universities, and verified organizations.
Refresh cadence
Listings are checked weekly where source data allows, with stale or closed programs removed from public results.
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Featured funding opportunities
Forecast to Publish a Notice of Funding Opportunity for SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)
HHS-NIH11
GRANTFEDERALEquity-Free
Amount variesOpen
Verified Jun 23, 2026
Small Business Innovation Research Program (SBIR) Phase II
HHS-ACL
GRANTFEDERALEquity-Free
Amount variesOpen
Verified Jun 23, 2026
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
HHS-NIH11
GRANTFEDERALEquity-Free
Amount variesOpen
Verified Jun 30, 2026
NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required)
HHS-NIH11
GRANTFEDERALEquity-Free
Amount variesOpen
Verified Jun 30, 2026
Small Business Innovation Research (SBIR) program, Phase I
HHS-ACL
GRANTFEDERALEquity-Free
Amount variesOpen
Verified Jul 14, 2026
AZ: ArizonaState Trade Expansion Program
Arizona Commerce Authority
GRANTSTATEEquity-Free
Amount variesOpen
Verified May 5, 2026
AZ: Arizona'sOpportunity for Business
Arizona Commerce Authority
GRANTSTATEEquity-Free
$9,000Open
Verified Jun 16, 2026
America's Seed Fund (SBIR/STTR)
U.S. Small Business Administration
GRANTFEDERALEquity-Free
$1,800,000Open
Verified Aug 12, 2026
NATIONAL CANCER INSTITUTE (NCI) SMALL BUSINESS INNOVATION RESEARCH (SBIR) INNOVATIVE CONCEPT PHASE I AWARD PROGRAM
HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.NIH A E CONSTRUCTION
GRANTFEDERALEquity-Free
Amount variesSep 21, 2026
Verified Jul 12, 2026
NATIONAL CANCER INSTITUTE (NCI) SMALL BUSINESS INNOVATION RESEARCH (SBIR) INNOVATIVE CONCEPT PHASE I AWARD PROGRAM
HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.NIH A E CONSTRUCTION
GRANTFEDERALEquity-Free
Amount variesSep 21, 2026
Verified Aug 12, 2026
Who SBIR is best for
SBIR is a fit for teams with a defensible technical innovation, a clear agency need, and the ability to write a research plan. It is usually not a fit for ordinary working capital or local-service businesses.
SBIR vs. other startup grants
Unlike many local small-business grants, SBIR is research-focused and competitive nationwide. It can be non-dilutive, but applications require technical detail, budgets, milestones, and agency alignment.
How to use this hub
Use the listings below to find live SBIR-related opportunities, then verify solicitation details, deadlines, agency requirements, and registrations on the official source page.